Establishment of Infectious Diseases

An infectious disease occurs when a pathogenic organism causes inflammation or organ dysfunction. This may be caused directly by the virus itself, as when the etiologic agent multiplies in the coordinator, or indirectly as a result from the host’s inflammatory response. Numerous infections are subclinical, not producing any obvious manifestations of illness.

To cause overt virus, all microorganisms should go via the following stages: The microorganism should (1) come across the host, (2) gain entry into the coordinator, (3) multiply and spread from the website of entry, and (4) trigger host tissue injury, either directly (eg, cytotoxins) or indirectly (host inflammatory response).

The severity of virus ranges from asymptomatic to life threatening, and the course may be characterized as acute, subacute, or chronic. Regardless of whether virus is subclinical or overt, the outcome is either (1) resolution (eg, eradication from the infecting pathogen), (a couple of) continual active virus (eg, HIV or hepatitis), (three) prolonged asymptomatic excretion of the agent (eg, carrier state with Salmonella typhi), (4) latency from the agent within coordinator tissues (eg, latent tuberculosis), or (5) coordinator death from virus.

Except for congenital infections (acquired in utero) caused by agents such as rubella virus, T pallidum, and cytomegalovirus, human beings first come across microorganisms at birth. During parturition, the newborn comes into contact with microorganisms existing within the mother’s vaginal canal and on her skin. Most from the bacteria the newborn encounters don’t trigger harm, and for those that might cause virus, the newborn usually has passive immunity via antibodies acquired from the mother in utero.

For example, neonates are protected against infection with H influenzae by maternal antibodies for the very first 6 months of existence until passive immunity wanes and also the chance of infection with this bacterium increases. On the other hand, newborns whose mothers are vaginally colonized with group B streptococci are at increased risk in the perinatal period for serious infections such as sepsis or meningitis with this organism.

Direct entry to the coordinator (ie, bypassing the usual chemical and physical barriers) occurs via penetration. This might occur when (1) an insect vector directly inoculates the infectious agent to the host (mosquitoes transmitting malaria), (2) bacteria gain direct access to coordinator tissues through loss of integrity from the skin or mucous membranes (trauma or surgical wounds), or (three) microbes gain access via instruments or catheters that permit communication between generally sterile websites and the outside world (eg, indwelling venous catheters).

Ingression occurs when an infectious agent enters the host via an orifice contiguous with the external environment. This primarily involves inhalation of infectious aerosolized droplets (M tuberculosis ) or ingestion of contaminated foods (salmonella, hepatitis A virus). Other infectious agents directly infect mucous membranes or cross the epithelial surface to cause virus.

This commonly happens in sexually transmitted diseases. For example, HIV can cross vaginal mucous membranes by penetration of virus-laden macrophages from semen. Right after the initial come across with the host, the infectious agent should successfully multiply at the site of entry.

The procedure whereby the newly introduced microorganism successfully competes with normal flora and is able to multiply is termed colonization (eg, pneumococci colonizing the upper respiratory tract). When the microorganism multiplies at a usually sterile site, it is termed virus (eg, pneumococci multiplying within the alveoli, causing pneumonia).

Elements that facilitate the multiplication and spread of infection include inoculum size (the quantity of infectious organisms released), coordinator anatomic factors (eg, impaired ciliary function in children with cystic fibrosis), availability of nutrients for the microbe, physicochemical factors (eg, gastric pH), microbial virulence elements, and microbial sanctuary (eg, abscesses).


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